Correlation Study between CYP2C8 Gene Polymorphim and Adverse Reaction of Paclitaxel in Cancer Patients / 中国药学杂志

OBJECTIVE: To investigate the correlation between CYP2C8 gene polymorphisms and the adverse reactions of paclitaxelin in cancer patients.METHODS: Fifty-two patients who received paclitaxel chemotherapy from January 2016 to May 2018 were selected as experimental subjects. The CYP2C8 genotypes of the selected patients were tested and the adverse reactions of paclitaxel were observed, collected and recorded to explore the relationship between adverse reactions and genetic polymorphism.RESULTS: In this study, 25 gene loci were detected, only 7 gene loci had mutation, and the remaining 18 gene loci were all wild-type.In the polymorphism of CYP2C8 gene,the incidence of thrombocytopenia and pain in patients with CYP2C8*1B(-271C>A) wild-type (CC) was significantly higher than that in mutant (CA+AA) (PT) wild-type gene (CC) was significantly lower than that in mutant gene (CT+TT) (P<0.05).CONCLUSION: The polymorphism of CYP2C8 gene may be associated with the adverse reaction of paclitaxel.

Association of angiotensin II receptor type 1 gene single nucleotide polymorphism with Chinese essential hypertension complicated with coronary heart disease / 中华心血管病杂志

<p><b>OBJECTIVE</b>To identify the genetic variants of angiotensin II type 1 receptor (AT1) gene in a population of Han ethnicity in east China and to determine whether the AT1 gene polymorphisms are associated with essential hypertension (EH) and coronary heart disease (CHD).</p><p><b>METHODS</b>The detection of single nucleotide polymorphisms (SNPs) was performed in 20 subjects by a direct DNA sequencing. All 213 EH patients, 171 patients of EH with CHD and 200 controls were genotyped by three detected SNPs.</p><p><b>RESULTS</b>Eight positive SNPs were detected in the promoter, exon and 3' untranslated region (3'UTR) of AT1 gene. A case-control study by using a frequent SNP (A-153G) in the promoter region, showed a significant increase in allele frequency of G-153 in the subjects of EH complicated with CHD (17.8% vs 11.5% for normal controls, P < 0.05). The SNP A1166C, which has been widely studied, manifested no difference in the three groups.</p><p><b>CONCLUSION</b>A polymorphism in the promoter region (A-153G) of AT1 gene might be involved in the development of EH and CHD in Han ethnicity population in east China.</p>